The Picower Institute for Learning and Memory, RIKEN-MIT Center for Neural Circuit Genetics, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Science. 2011 Dec 9;334(6061):1415-20. doi: 10.1126/science.1210125. Epub 2011 Nov 3.
Associating temporally discontinuous elements is crucial for the formation of episodic and working memories that depend on the hippocampal-entorhinal network. However, the neural circuits subserving these associations have remained unknown. The layer III inputs of the entorhinal cortex to the hippocampus may contribute to this process. To test this hypothesis, we generated a transgenic mouse in which these inputs are specifically inhibited. The mutant mice displayed significant impairments in spatial working-memory tasks and in the encoding phase of trace fear-conditioning. These results indicate a critical role of the entorhinal cortex layer III inputs to the hippocampus in temporal association memory.
关联不连续的元素对于依赖海马 - 内嗅网络的情景记忆和工作记忆的形成至关重要。然而，支持这些关联的神经回路仍然未知。内嗅皮层到海马的 III 层输入可能有助于这个过程。为了验证这一假设，我们生成了一种转基因小鼠，其中这些输入被特异性抑制。突变小鼠在空间工作记忆任务和痕迹恐惧条件反射的编码阶段表现出明显的损伤。这些结果表明内嗅皮层到海马的 III 层输入在时间关联记忆中起着关键作用。
