Romero Pedro, Méndez Isabel, Salvat Merce, Fernández Juan, Almena Matias
Servicio de Oftalmología, Hospital Universitario Sant Joan de Reus, Departamento de Medicina y Cirugía, Universidad Rovira y Virgili, Reus, Spain.
J Cataract Refract Surg. 2006 Mar;32(3):438-41. doi: 10.1016/j.jcrs.2005.12.135.
To evaluate the efficacy of prophylactic intracameral cefazolin in preventing endophthalmitis in cataract surgery.
Service of Ophthalmology, St. Joan Hospital, Reus, Spain.
In this noncontrolled retrospective observational study, all patients had uncombined cataract surgery from January 2001 to December 2004. All cases of postoperative endophthalmitis were related. The patients were classified into 2 groups. The first (n = 3650) had surgery between January 2001 and December 2002, and the second (n = 3618) had surgery between January 2003 and December 2004; the second group received a bolus of intracameral cefazolin instilled at the end of surgery.
The rate of postoperative endophthalmitis was lower in the cases with intracameral injection at the end of surgery (0.055%) than in those without cefazolin injection (0.63%). No patients in the group with intracameral cefazoline developed corneal endothelium or retinal toxicity.
Intracameral bolus injection of cefazolin (1 mg in 0.1 mL solution) in cataract surgery demonstrated prophylactic efficacy in diminishing the rate of postoperative endophthalmitis without toxic effects on the cornea or retina.
评估术中前房内注射头孢唑林预防白内障手术眼内炎的疗效。
西班牙雷乌斯圣琼医院眼科。
在这项非对照回顾性观察研究中，所有患者于2001年1月至2004年12月接受单纯白内障手术。所有术后眼内炎病例均有关联。患者被分为两组。第一组（n = 3650）于2001年1月至2002年12月接受手术，第二组（n = 3618）于2003年1月至2004年12月接受手术；第二组在手术结束时接受前房内注射一剂头孢唑林。
手术结束时接受前房内注射的病例术后眼内炎发生率（0.055%）低于未注射头孢唑林的病例（0.63%）。接受前房内注射头孢唑林的组中没有患者出现角膜内皮或视网膜毒性。
白内障手术中前房内注射一剂头孢唑林（1毫克溶于0.1毫升溶液）显示出预防疗效，可降低术后眼内炎发生率，且对角膜或视网膜无毒性作用。
