眼内注射头孢呋辛预防白内障手术后眼内炎的效果：十年对比研究。

Effectiveness of intracameral cefuroxime in preventing endophthalmitis after cataract surgery Ten-year comparative study.

机构信息

University Hospital Fundación Alcorcón, Madrid, Spain.

出版信息

J Cataract Refract Surg. 2010 Feb;36(2):203-7. doi: 10.1016/j.jcrs.2009.08.023.

DOI:10.1016/j.jcrs.2009.08.023

PMID:20152598

Abstract

PURPOSE

To determine the differences in the endophthalmitis rates in cataract surgery before and after prophylactic use of intracameral cefuroxime.

SETTING

University Hospital Fundación Alcorcón, Madrid, Spain.

METHODS

This prospective study evaluated patients who had cataract surgery at a university eye center over a 10-year period (1999 to 2008). Since the protocol's approval by the Hospital Board in October 2005 to the end of the 10-year period, cataract patients were routinely treated with prophylactic intracameral cefuroxime. A database was used to measure the occurrence of endophthalmitis postoperatively. Then, the incidence of endophthalmitis before and after generalized use of prophylactic cefuroxime was compared. The effect of cefuroxime was evaluated by the relative risk.

RESULTS

From January 1999 to December 2008, 13 652 patients had cataract surgery. Forty-two cases of postoperative bacterial endophthalmitis were reported. The endophthalmitis rate was 0.30% (95% confidence interval [CI], 0.26%-0.35%) overall, 0.59% (95% CI, 0.50%-0.70%) from January 1999 to September 2005, and 0.043% (95% CI, 0.02%-0.06%) from October 2005 to December 2008. The relative risk was 0.07 (range 0.022 to 0.231; P<.05).

CONCLUSION

Intracameral cefuroxime proved to be effective in reducing the risk for acute-onset endophthalmitis after cataract surgery.

摘要

目的

确定白内障手术中预防性使用头孢呋辛前后眼内炎发生率的差异。

地点

西班牙马德里阿尔科孔大学医院。

方法

本前瞻性研究评估了在大学眼科中心进行白内障手术的患者，时间跨度为 10 年（1999 年至 2008 年）。自 2005 年 10 月医院委员会批准该方案至 10 年结束，白内障患者常规接受预防性眼内头孢呋辛治疗。使用数据库来衡量术后眼内炎的发生情况。然后，比较预防性使用头孢呋辛前后眼内炎的发生率。通过相对风险评估头孢呋辛的效果。

结果

1999 年 1 月至 2008 年 12 月，有 13652 名患者接受了白内障手术。报告了 42 例术后细菌性眼内炎病例。总的眼内炎发生率为 0.30%（95%置信区间，0.26%-0.35%），1999 年 1 月至 2005 年 9 月为 0.59%（95%置信区间，0.50%-0.70%），2005 年 10 月至 2008 年 12 月为 0.043%（95%置信区间，0.02%-0.06%）。相对风险为 0.07（范围 0.022 至 0.231；P<.05）。