香港地区大豆摄入量与死亡率：1998年对所有老年成人死亡病例进行代理报告的病例对照研究

Soy consumption and mortality in Hong Kong: proxy-reported case-control study of all older adult deaths in 1998.

作者信息

Ho Sai-Yin, Schooling Mary, Hui Lai-Ling, McGhee Sarah M, Mak Kwok-Hang, Lam Tai-Hing

机构信息

Department of Community Medicine, The University of Hong Kong, Hong Kong SAR, PR China.

出版信息

Prev Med. 2006 Jul;43(1):20-6. doi: 10.1016/j.ypmed.2006.03.007. Epub 2006 May 2.

DOI:10.1016/j.ypmed.2006.03.007

PMID:16631248

Abstract

OBJECTIVES

This study investigates the relation between soy consumption and mortality in a population-based case-control study in Hong Kong of all adult deaths in 1998.

METHODS

Multivariable logistic regression was used to assess the effect of soy on all-cause and cause-specific mortality in 21,494 deceased cases and 10,968 living controls who were ethnic Chinese aged 60 or above, using proxy reports collected from the person registering the death. Dietary habits were obtained from proxies in both cases and controls, based on a 7-item questionnaire.

RESULTS

The adjusted odds ratios for all-cause mortality for soy consumption 4 or more times a week compared with less than once a month were 0.77 (95% CI: 0.62, 0.95) for men and 0.66 (0.54, 0.81) for women. Mortality from lung cancer (males P = 0.02, females P = 0.02), colorectal cancer (males P = 0.07, females P < 0.001), stomach cancer (males P = 0.04, females P = 0.03), female breast cancer (P = 0.02) and ischemic heart disease (males P < 0.001, females P = 0.002) was inversely associated with soy consumption.

CONCLUSIONS

Our study suggests that maintaining traditional levels of soy consumption could be protective for some chronic diseases in China.

摘要

目的

本研究在一项基于人群的病例对照研究中，调查了1998年香港所有成年死亡病例中大豆摄入量与死亡率之间的关系。

方法

采用多变量逻辑回归分析，通过从死亡登记人处收集的代理报告，评估大豆对21494例死亡病例和10968例60岁及以上的华裔在世对照者的全因死亡率和特定病因死亡率的影响。基于一份包含7个条目的问卷，从病例组和对照组的代理报告中获取饮食习惯信息。

结果

每周食用大豆4次或更多次与每月食用不到1次相比，男性全因死亡率的调整比值比为0.77（95%可信区间：0.62，0.95），女性为0.66（0.54，0.81）。肺癌（男性P = 0.02，女性P = 0.02）、结直肠癌（男性P = 0.07，女性P < 0.001）、胃癌（男性P = 0.04，女性P = 0.03）、女性乳腺癌（P = 0.02）和缺血性心脏病（男性P < 0.001，女性P = 0.002）的死亡率与大豆摄入量呈负相关。