管理严重肢体缺血中动脉粥样硬化的危险因素。

Managing risk factors for atherosclerosis in critical limb ischaemia.

作者信息

Gottsäter A

机构信息

University of Lund, Department of Vascular Diseases, Malmö University Hospital, S-205 02 Malmö, Sweden.

出版信息

Eur J Vasc Endovasc Surg. 2006 Nov;32(5):478-83. doi: 10.1016/j.ejvs.2006.03.007. Epub 2006 Apr 24.

DOI:10.1016/j.ejvs.2006.03.007

PMID:16631394

Abstract

OBJECTIVE

To review the best medical management of critical limb ischaemia (CLI).

METHODS

Published studies dealing with CLI and risk factors were searched for via PUBMED.

FINDINGS AND CONCLUSIONS

Patients with critical limb ischaemia (CLI) have a one and ten year mortality of approximately 20% and 75% respectively. Risk factors for the development of peripheral atherosclerosis are the same as for coronary and cerebrovascular atherosclerosis namely diabetes mellitus, hyperlipidaemia, arterial hypertension, and smoking. As there are few studies of risk factor for peripheral arterial occlusive disease (PAOD), treatment recommendations are often based on studies in patients with coronary or cerebrovascular atherosclerosis. While waiting for specific studies, CLI patients should be treated according to current guidelines for other atherosclerotic patients.

摘要

目的

回顾下肢严重缺血（CLI）的最佳药物治疗方法。

方法

通过PUBMED搜索已发表的关于CLI及其危险因素的研究。

研究结果与结论

下肢严重缺血（CLI）患者的1年和10年死亡率分别约为20%和75%。外周动脉粥样硬化发展的危险因素与冠状动脉和脑血管粥样硬化相同，即糖尿病、高脂血症、动脉高血压和吸烟。由于关于外周动脉闭塞性疾病（PAOD）危险因素的研究较少，治疗建议通常基于对冠状动脉或脑血管粥样硬化患者的研究。在等待特定研究结果期间，CLI患者应按照当前针对其他动脉粥样硬化患者的指南进行治疗。