Sobti R C, Kaur Satinder, Kaur Pushpinder, Singh Jagmohan, Gupta Indu, Jain Veena, Nakahara A
Department of Biotechnology, Panjab University, Chandigarh 160014, India.
Cancer Genet Cytogenet. 2006 Apr 15;166(2):117-23. doi: 10.1016/j.cancergencyto.2005.10.001.
Human papilloma virus (HPV) infection is a major cause of cervix cancer, but a number of infected women do not develop invasive lesions, suggesting that HPV infection in itself is not a sufficient factor and that other cofactors, such as smoking, play an important role in development of cervix cancer. Alongside active cigarette smoking, passive smoking is an independent risk factor for cervix cancer. Smoking maintains cervical HPV infection longer and decreases potential of clearing an oncogenic infection. Thus, it is quite possible that polymorphism at detoxifying enzyme coding loci such as GSTM1, GSTT1, and GSTP1 may determine susceptibility to cervix cancer. This study evaluates the combined effects of genetic polymorphisms of GSTM1, GSTT1, and GSTP1 on susceptibility to cervical cancer and interaction of these genes with smoking. On individual analysis of GSTM1, GSTT1, and GSTP1, it was observed that passive smokers having genotypes GSTM1 (null) (OR = 7.0, 95% CI = 2.19-22.36, P = 0.0005), GSTT1 (null) (OR = 10.2, 95% CI = 1.23-84.18, P = 0.02), and GSTP1 (ile/val) (OR = 6.4, 95% CI = 2.25-18.38, P = 0.0005) have an increased risk of developing cervix cancer. It is thus concluded that cervical cancer risk is increased in passive smokers with GSTM1 (null), GSTT1 (null), and GSTP1 (ile/val) genotypes.
人乳头瘤病毒（HPV）感染是宫颈癌的主要病因，但许多感染该病毒的女性并未发展为浸润性病变，这表明HPV感染本身并非充分因素，而其他辅助因素，如吸烟，在宫颈癌的发展中起着重要作用。除主动吸烟外，被动吸烟也是宫颈癌的独立危险因素。吸烟会使宫颈HPV感染持续更长时间，并降低清除致癌感染的可能性。因此，解毒酶编码基因座（如GSTM1、GSTT1和GSTP1）的多态性很可能决定个体对宫颈癌的易感性。本研究评估了GSTM1、GSTT1和GSTP1基因多态性对宫颈癌易感性的综合影响，以及这些基因与吸烟的相互作用。对GSTM1、GSTT1和GSTP1进行个体分析时发现，基因型为GSTM1（无效）（比值比[OR]=7.0，95%置信区间[CI]=2.19-22.36，P=0.0005）、GSTT1（无效）（OR=10.2，95%CI=1.23-84.18，P=0.02）和GSTP1（异亮氨酸/缬氨酸）（OR=6.4，95%CI=2.25-18.38，P=0.0005）的被动吸烟者患宫颈癌的风险增加。因此得出结论，基因型为GSTM1（无效）、GSTT1（无效）和GSTP1（异亮氨酸/缬氨酸）的被动吸烟者患宫颈癌的风险增加。
