Zhao Erjiang, Hu Kai, Zhao Yan
Affiliated Tumor Hospital of Zhengzhou University, Henan Tumor Hospital, Zhengzhou, China.
Henan Academy of Medical Sciences, Zhengzhou, Henan, China.
Oncotarget. 2017 Jun 20;8(25):41734-41739. doi: 10.18632/oncotarget.16764.
The association between the glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism and gynecological cancer susceptibility has been evaluated in many studies. However, the results remain controversial. Thus, this meta-analysis, based on 10 published case-control studies, was designed to clarify the association of the GSTP1 Ile105Val polymorphism with gynecological cancer risk. Our results suggested that there was no significant association between the GSTP1 Ile105Val polymorphism and the risk of gynecological cancer in all genetic models (GG vs. AA: odds ratio [OR] = 1.41, 95% confidence interval [CI] = 0.75-2.26; AG vs. AA: OR = 1.13, 95% CI = 0.74-1.73; AG/GG vs. AA: OR = 1.17, 95% CI = 0.75-1.81; GG vs.
AA/AG: OR = 1.38, 95% CI = 0.79-2.42). Similarly, in the subgroup analyses by cancer type, ethnicity, and smoking status, no significant association with any genetic model was observed. In conclusion, the results of our meta-analysis suggest that the GSTP1 Ile105Val polymorphism is not associated with the development of gynecological cancer.
许多研究已评估了谷胱甘肽S-转移酶P1（GSTP1）Ile105Val多态性与妇科癌症易感性之间的关联。然而，结果仍存在争议。因此，本荟萃分析基于10项已发表的病例对照研究，旨在阐明GSTP1 Ile105Val多态性与妇科癌症风险的关联。我们的结果表明，在所有遗传模型中，GSTP1 Ile105Val多态性与妇科癌症风险之间均无显著关联（GG与AA：比值比[OR]=1.41，95%置信区间[CI]=0.75-2.26；AG与AA：OR=1.13，95%CI=0.74-1.73；AG/GG与AA：OR=1.17，95%CI=0.75-1.81；GG与AA/AG：OR=1.38，95%CI=0.79-2.42）。同样，在按癌症类型、种族和吸烟状况进行的亚组分析中，未观察到与任何遗传模型有显著关联。总之，我们的荟萃分析结果表明，GSTP1 Ile105Val多态性与妇科癌症的发生无关。
