Kolas Nadine K, Durocher Daniel
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Curr Biol. 2006 Apr 18;16(8):R296-9. doi: 10.1016/j.cub.2006.03.043.
DNA polymerase zeta and Rev1 play key roles in replication past DNA lesions. New work shows that the yeast checkpoint kinase Mec1 recruits a complex consisting of polymerase zeta and Rev1 to DNA double-strand breaks. This study highlights the role of polymerases that mediate translesion synthesis in the response to DNA double-strand breaks.
DNA聚合酶ζ和Rev1在绕过DNA损伤进行复制过程中发挥关键作用。新的研究表明，酵母检查点激酶Mec1将由聚合酶ζ和Rev1组成的复合物招募至DNA双链断裂处。这项研究突出了介导跨损伤合成的聚合酶在应对DNA双链断裂中的作用。
