DNA修复：DNA聚合酶ζ与Rev1介入。
DNA repair: DNA polymerase zeta and Rev1 break in.
作者信息
Kolas Nadine K, Durocher Daniel
机构信息
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
出版信息
Curr Biol. 2006 Apr 18;16(8):R296-9. doi: 10.1016/j.cub.2006.03.043.
PMID:16631579
Abstract
DNA polymerase zeta and Rev1 play key roles in replication past DNA lesions. New work shows that the yeast checkpoint kinase Mec1 recruits a complex consisting of polymerase zeta and Rev1 to DNA double-strand breaks. This study highlights the role of polymerases that mediate translesion synthesis in the response to DNA double-strand breaks.
摘要
DNA聚合酶ζ和Rev1在绕过DNA损伤进行复制过程中发挥关键作用。新的研究表明，酵母检查点激酶Mec1将由聚合酶ζ和Rev1组成的复合物招募至DNA双链断裂处。这项研究突出了介导跨损伤合成的聚合酶在应对DNA双链断裂中的作用。
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