Mitsuma Wataru, Ito Masahiro, Kodama Makoto, Fuse Koichi, Okamura Kazuki, Minagawa Shiro, Kato Kiminori, Hanawa Haruo, Toba Ken, Nakazawa Mikio, Aizawa Yoshifusa
Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Japan.
Biochem Biophys Res Commun. 2006 Jun 9;344(3):987-94. doi: 10.1016/j.bbrc.2006.03.230. Epub 2006 Apr 19.
Erythropoietin (EPO) has been known to have cytoprotective effects on several types of tissues, presumably through modulation of apoptosis and inflammation. The effect of EPO on myocardial inflammation, however, has not yet been clarified. We investigated the cardioprotective effects of EPO in rats with experimental autoimmune myocarditis (EAM). Seven-week-old Lewis rats immunized with cardiac myosin were treated either with EPO or vehicle and were examined on day 22. EPO attenuated the functional and histological severity of EAM along with suppression of mRNAs of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 in the hearts as well as a reduction of apoptotic cardiomyocytes. The EPO receptor (EPO-R) was upregulated in the myocardium of EAM compared with that of healthy rats. These results may suggest that EPO ameliorated the progression of EAM by modulating myocardial inflammation and apoptosis.
已知促红细胞生成素（EPO）对多种组织具有细胞保护作用，可能是通过调节细胞凋亡和炎症来实现的。然而，EPO对心肌炎症的影响尚未阐明。我们研究了EPO对实验性自身免疫性心肌炎（EAM）大鼠的心脏保护作用。用心肌肌凝蛋白免疫的7周龄Lewis大鼠，分别给予EPO或赋形剂处理，并在第22天进行检查。EPO减轻了EAM的功能和组织学严重程度，同时抑制了心脏中肿瘤坏死因子（TNF）-α和白细胞介素（IL）-6的mRNA表达，并减少了凋亡心肌细胞。与健康大鼠相比，EAM大鼠心肌中的EPO受体（EPO-R）上调。这些结果可能表明，EPO通过调节心肌炎症和细胞凋亡改善了EAM的进展。
