Pifferi Simone, Boccaccio Anna, Menini Anna
International School for Advanced Studies, S.I.S.S.A., Sector of Neurobiology, Via Beirut 2-4, 34014 Trieste, Italy.
FEBS Lett. 2006 May 22;580(12):2853-9. doi: 10.1016/j.febslet.2006.03.086. Epub 2006 Apr 12.
Cyclic nucleotide-gated (CNG) channels, directly activated by the binding of cyclic nucleotides, were first discovered in retinal rods, cones and olfactory sensory neurons. In the visual and olfactory systems, CNG channels mediate sensory transduction by conducting cationic currents carried primarily by sodium and calcium ions. In olfactory transduction, calcium in combination with calmodulin exerts a negative feedback on CNG channels that is the main molecular mechanism responsible for fast adaptation in olfactory sensory neurons. Six mammalian CNG channel genes are known and some human visual disorders are caused by mutations in retinal rod or cone CNG genes.
环核苷酸门控（CNG）通道由环核苷酸结合直接激活，最初在视网膜视杆细胞、视锥细胞和嗅觉感觉神经元中被发现。在视觉和嗅觉系统中，CNG通道通过传导主要由钠离子和钙离子携带的阳离子电流来介导感觉转导。在嗅觉转导中，钙与钙调蛋白结合对CNG通道产生负反馈，这是嗅觉感觉神经元快速适应的主要分子机制。已知有六个哺乳动物CNG通道基因，一些人类视觉障碍是由视网膜视杆或视锥CNG基因突变引起的。
