Gaya Daniel R, Russell Richard K, Nimmo Elaine R, Satsangi Jack
Gastrointestinal Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
Lancet. 2006 Apr 15;367(9518):1271-84. doi: 10.1016/S0140-6736(06)68345-1.
The chronic inflammatory bowel diseases Crohn's disease and ulcerative colitis are common causes of gastrointestinal disease in northern Europe, affecting as many as one in 250 people. Although mortality is low, morbidity associated with these diseases is substantial. We review the recent advances in the genetics of inflammatory bowel disease, with particular emphasis on the data that have been generated since the discovery of the CARD15 (NOD2) gene in 2001.
慢性炎症性肠病，如克罗恩病和溃疡性结肠炎，是北欧胃肠道疾病的常见病因，每250人中就有1人受其影响。尽管死亡率较低，但这些疾病相关的发病率却相当高。我们综述了炎症性肠病遗传学的最新进展，特别强调自2001年发现CARD15（NOD2）基因以来所产生的数据。
