Hsiao Pa-Fan, Hsiao Cheng-Hsiang, Tsai Tsen-Fang, Jee Shiou-Hwa
Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan.
J Am Acad Dermatol. 2006 May;54(5 Suppl):S198-201. doi: 10.1016/j.jaad.2005.08.044.
We describe the case of a 13-year-old boy with stage I hypopigmented mycosis fungoides in whom minimal residual disease was detected with T-cell receptor gamma-polymerase chain reaction after the disease was in complete clinical remission. We further cloned and sequenced the T-cell receptor gamma-polymerase chain reaction product of the lesion in remission and found that the original T-cell clone still existed in decreased amounts. The patient was followed up for 3 1/2 years without any new lesions developing. The clinical significance of this residual malignant T-cell clone in mycosis fungoides remains to be elucidated.
我们描述了一名13岁患有Ⅰ期色素减退性蕈样肉芽肿的男孩的病例，该患者在疾病完全临床缓解后，通过T细胞受体γ-聚合酶链反应检测到微小残留病。我们进一步对缓解期病变的T细胞受体γ-聚合酶链反应产物进行克隆和测序，发现原来的T细胞克隆仍以减少的数量存在。该患者接受了3年半的随访，没有出现任何新病变。蕈样肉芽肿中这种残留恶性T细胞克隆的临床意义仍有待阐明。
