感染包膜蛋白糖基化或非糖基化西尼罗河病毒的小鼠腹腔巨噬细胞中促炎细胞因子的动力学
The kinetics of proinflammatory cytokines in murine peritoneal macrophages infected with envelope protein-glycosylated or non-glycosylated West Nile virus.
作者信息
Shirato Kazuya, Miyoshi Hirotsugu, Kariwa Hiroaki, Takashima Ikuo
机构信息
Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita-18 Nishi-9, Sapporo, 060-0818, Japan.
出版信息
Virus Res. 2006 Oct;121(1):11-6. doi: 10.1016/j.virusres.2006.03.010. Epub 2006 Apr 24.
The envelope (E) protein glycosylation status of the New York strain of West Nile (WN) virus is an important determinant of virus neuroinvasiveness. To elucidate the determinant of the difference between E protein-glycosylated and non-glycosylated WN virus infections, the cytokine expression of murine peritoneal macrophages infected with each virus was examined. Tumor necrosis factor (TNF) alpha and interleukin (IL)-1beta were up-regulated with replication of the E protein-glycosylated virus. Interferon (IFN) beta and IL-6 were up-regulated with the clearance of both viruses. These results suggest that TNFalpha and IL-1beta expression are related to the virulence of E protein-glycosylated WN virus.
西尼罗河（WN）病毒纽约株的包膜（E）蛋白糖基化状态是病毒神经侵袭性的重要决定因素。为阐明E蛋白糖基化和非糖基化WN病毒感染之间差异的决定因素，检测了感染每种病毒的小鼠腹腔巨噬细胞的细胞因子表达。随着E蛋白糖基化病毒的复制，肿瘤坏死因子（TNF）α和白细胞介素（IL）-1β上调。随着两种病毒的清除，干扰素（IFN）β和IL-6上调。这些结果表明，TNFα和IL-1β的表达与E蛋白糖基化WN病毒的毒力有关。
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