Wang T, Anderson J F, Magnarelli L A, Bushmich S, Wong S, Koski R A, Fikrig E
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, 06520, USA.
Ann N Y Acad Sci. 2001 Dec;951:325-7.
The role of antibodies to the West Nile virus envelope (E) protein in serodiagnosis and protection was examined. The E protein was expressed and purified in recombinant form. Antibodies to the E protein were detected in patients with West Nile virus infection. Passive immunization with rabbit anti-E protein sera also partially protected mice from challenge with West Nile virus. The humoral response to the West Nile virus E protein is therefore useful as an aid in the diagnosis and may also play a role in immunity to infection.
研究了西尼罗河病毒包膜（E）蛋白抗体在血清学诊断和保护中的作用。以重组形式表达并纯化了E蛋白。在西尼罗河病毒感染患者中检测到了针对E蛋白的抗体。用兔抗E蛋白血清进行被动免疫也能部分保护小鼠免受西尼罗河病毒攻击。因此，针对西尼罗河病毒E蛋白的体液反应有助于诊断，也可能在抗感染免疫中发挥作用。
