Littlewood Timothy J, Kallich Joel D, San Miguel Jesus, Hendricks Lisa, Hedenus Michael
John Radcliffe Hospital, Oxford, United Kingdom.
J Pain Symptom Manage. 2006 Apr;31(4):317-25. doi: 10.1016/j.jpainsymman.2005.08.013.
Anemia-related fatigue in cancer patients reduces health-related quality of life (HRQOL). These analyses evaluate the effect of hemoglobin level on fatigue and examine the relationship between improved fatigue and HRQOL. Data were collected during a multicenter, randomized trial involving 344 anemic patients with lymphoproliferative malignancies receiving chemotherapy and darbepoetin alfa or placebo. At baseline, interim study visits, and end of treatment, patients completed an HRQOL questionnaire. Improved hemoglobin levels were significantly associated (P < 0.001) with improved fatigue. Mean change in the Functional Assessment of Cancer Therapy (FACT) Fatigue score was 5.9 points greater when hemoglobin improved > 2 g/dl than when it declined. Patients experiencing a clinically meaningful improvement in fatigue reported significantly (P < 0.001) greater improvements in all other scales, except the FACT Social subscale. Managing anemia-related fatigue appears to have a positive impact on HRQOL, enhancing cancer patients' activity levels, mood, and perceived overall health.
癌症患者中与贫血相关的疲劳会降低健康相关生活质量（HRQOL）。这些分析评估血红蛋白水平对疲劳的影响，并研究疲劳改善与HRQOL之间的关系。数据收集于一项多中心随机试验，该试验涉及344例接受化疗及达贝泊汀α或安慰剂治疗的患有淋巴增生性恶性肿瘤的贫血患者。在基线、中期研究访视和治疗结束时，患者完成一份HRQOL问卷。血红蛋白水平的改善与疲劳改善显著相关（P < 0.001）。当血红蛋白改善> 2 g/dl时，癌症治疗功能评估（FACT）疲劳评分的平均变化比血红蛋白下降时高5.9分。在疲劳方面有临床意义改善的患者在所有其他量表上（除FACT社会子量表外）的改善均显著（P < 0.001）。管理与贫血相关的疲劳似乎对HRQOL有积极影响，可提高癌症患者的活动水平、情绪和整体健康感知。
