Mofid Bahram, Rezaeizadeh Hossein, Termos Abdulkarim, Rakhsha Afshin, Mafi Ahmad Rezazadeh, Taheripanah Taiebeh, Ardakani Mehran Mirabzadeh, Taghavi Seyed Mohammad Esmaeil, Moravveji Seyyed Alireza, Kashi Amir Shahram Yousefi
Associate Professor, Shohada-e-Tajrish Hospital, Department of Radiation Oncology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
M.D, Ph.D. of Traditional Persian Medicine, Assistant Professor, Department of Traditional Persian Medicine, School of Traditional Medicine, Tehran University of Medical Science, Tehran, Iran.
Electron Physician. 2016 Jun 25;8(6):2475-82. doi: 10.19082/2475. eCollection 2016 Jun.
Cancer-related fatigue (CRF) is experienced by 50% to 90% of cancer patients and can severely affect their quality of life and functional capacity. Several randomized trials have recommended various ways to alleviate the symptoms of CRF with or without recourse to medications.
The aim of this study is to evaluate the effectiveness of processed honey and royal jelly on the symptoms of CRF in cancer patients who are undergoing hormone therapy, chemotherapy, chemo-radiation, or radiotherapy.
Fifty-two participants from the patients who visited the oncology clinic of Shohada-e-Tajrish hospital in Tehran (Iran) between May 2013 and August 2014 were selected and divided into two groups. The study group (26 patients) received processed honey and royal jelly, while the control group received pure honey. Both groups were instructed to consume their 5mL supplement twice daily for 4 weeks. Both groups were assessed at the beginning of the study, after 2 weeks, and then at the end of 4 weeks of treatment. Fatigue was measured using a visual analogue fatigue scale (VAFS) and fatigue severity scale (FSS). The results were compared between the two arms of study, and equality of probability distributions was assessed using a Kolmogorov-Smirnov test.
The mean age of the 52 patients was 54.84. After two and four weeks of treatment with processed honey and royal jelly, VAFS and FSS due to treatment was better in the study group than in the control group, and the differences were statistically significant (p<0.001, p<0.001, respectively).
To the best of our knowledge, our study provided support for the use of processed honey and royal jelly to ameliorate CRF. The positive results of this study warrant further studies in this field.
The study was registered in the Iranian Clinical Trial Registry Center (http://www.irct.ir) with the registration code: IRCT2015081423426N1.
The authors received no financial support for the research, authorship, and/or publication of this article.
50%至90%的癌症患者会经历癌症相关疲劳（CRF），这会严重影响他们的生活质量和功能能力。多项随机试验推荐了各种缓解CRF症状的方法，无论是否借助药物。
本研究旨在评估加工蜂蜜和蜂王浆对接受激素治疗、化疗、放化疗或放疗的癌症患者CRF症状的有效性。
选取2013年5月至2014年8月间在伊朗德黑兰Shohada - e - Tajrish医院肿瘤门诊就诊的52名患者，分为两组。研究组（26例患者）服用加工蜂蜜和蜂王浆，对照组服用纯蜂蜜。两组均被要求每天两次服用5毫升补充剂，持续4周。在研究开始时、2周后以及治疗4周结束时对两组进行评估。使用视觉模拟疲劳量表（VAFS）和疲劳严重程度量表（FSS）测量疲劳程度。比较研究的两组结果，并使用柯尔莫哥洛夫 - 斯米尔诺夫检验评估概率分布的相等性。
52例患者的平均年龄为54.84岁。在用加工蜂蜜和蜂王浆治疗两周和四周后，研究组因治疗导致的VAFS和FSS均优于对照组，差异具有统计学意义（分别为p<0.001，p<0.001）。
据我们所知，我们的研究为使用加工蜂蜜和蜂王浆改善CRF提供了支持。本研究的积极结果值得在该领域进一步开展研究。
该研究在伊朗临床试验注册中心（http://www.irct.ir）注册，注册号：IRCT2015081423426N1。
作者未获得该研究、撰写和/或发表本文的资金支持。
