Graf Rolf, Bimmler Daniel
Pancreatitis Research Laboratory, Department of Visceral and Transplantation Surgery, University Hospital Zürich, DL 34, Rämistrasse 100, Zürich 8091, Switzerland.
Endocrinol Metab Clin North Am. 2006 Jun;35(2):333-43, ix. doi: 10.1016/j.ecl.2006.02.005.
This article summarizes structural and functional properties of pancreatic secretory trypsin inhibitor (PSTI), which has been identified in many species. Its prominent role is to protect the pancreas from prematurely activated trypsinogen before entry into the duodenum. In the rat there are two isoforms, one of which is PSTI-I, a 61-amino acid peptide involved in the feedback regulation of pancreatic enzymes. Independent investigations in neoplastic diseases led to the discovery of tumor-associated trypsin inhibitor,which is identical to PSTI.
本文总结了在许多物种中都已鉴定出的胰腺分泌型胰蛋白酶抑制剂（PSTI）的结构和功能特性。其突出作用是在胰蛋白酶原进入十二指肠之前保护胰腺免受过早激活。在大鼠中有两种同工型，其中一种是PSTI-I，一种参与胰腺酶反馈调节的61个氨基酸的肽。对肿瘤性疾病的独立研究导致发现了与PSTI相同的肿瘤相关胰蛋白酶抑制剂。
