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大鼠胰腺胆囊收缩素(CCK)释放肽(监测肽)及胰腺分泌性胰蛋白酶抑制剂(PSTI)编码基因的分子克隆与特性分析

Molecular cloning and characterization of genes encoding rat pancreatic cholecystokinin (CCK)-releasing peptide (monitor peptide) and pancreatic secretory trypsin inhibitor (PSTI).

作者信息

Tsuzuki S, Miura Y, Fushiki T, Oomori T, Satoh T, Natori Y, Sugimoto E

机构信息

Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Japan.

出版信息

Biochim Biophys Acta. 1992 Sep 24;1132(2):199-202. doi: 10.1016/0167-4781(92)90012-o.

DOI:10.1016/0167-4781(92)90012-o
PMID:1390891
Abstract

The genes encoding a rat pancreatic cholecystokinin (CCK)-releasing peptide (monitor peptide) and its structurally related peptide, rat pancreatic secretory trypsin inhibitor (PSTI), have been isolated and sequenced. The two genes share extremely high sequence similarity in the 5' flanking regions, suggesting that these regions may be responsible for the characteristic coordinate expression of the two peptides.

摘要

编码大鼠胰腺胆囊收缩素(CCK)释放肽(监测肽)及其结构相关肽——大鼠胰腺分泌型胰蛋白酶抑制剂(PSTI)的基因已被分离并测序。这两个基因在5'侧翼区域具有极高的序列相似性,表明这些区域可能负责这两种肽的特征性协同表达。

相似文献

1
Molecular cloning and characterization of genes encoding rat pancreatic cholecystokinin (CCK)-releasing peptide (monitor peptide) and pancreatic secretory trypsin inhibitor (PSTI).大鼠胰腺胆囊收缩素(CCK)释放肽(监测肽)及胰腺分泌性胰蛋白酶抑制剂(PSTI)编码基因的分子克隆与特性分析
Biochim Biophys Acta. 1992 Sep 24;1132(2):199-202. doi: 10.1016/0167-4781(92)90012-o.
2
On the cDNA's for two types of rat pancreatic secretory trypsin inhibitor.关于两种大鼠胰腺分泌型胰蛋白酶抑制剂的互补脱氧核糖核酸。
Biochem Biophys Res Commun. 1989 Jul 14;162(1):151-9. doi: 10.1016/0006-291x(89)91975-x.
3
Complementary nucleotide sequence for monitor peptide, a novel cholecystokinin-releasing peptide in the rat.用于监测肽的互补核苷酸序列,一种大鼠中的新型胆囊收缩素释放肽。
Nucleic Acids Res. 1989 Dec 11;17(23):10111. doi: 10.1093/nar/17.23.10111.
4
On the genomic organization of the human pancreatic secretory trypsin inhibitor.关于人胰腺分泌型胰蛋白酶抑制剂的基因组组织
Biol Chem Hoppe Seyler. 1988 May;369 Suppl:51-4.
5
Effect of a high-protein diet on the gene expression of a trypsin-sensitive, cholecystokinin-releasing peptide (monitor peptide) in the pancreas.高蛋白饮食对胰腺中一种胰蛋白酶敏感的胆囊收缩素释放肽(监测肽)基因表达的影响。
Eur J Biochem. 1991 Jul 1;199(1):245-52. doi: 10.1111/j.1432-1033.1991.tb16116.x.
6
Rapid and selective cloning of monitor peptide, a novel cholecystokinin-releasing peptide, using minimal amino acid sequence and the polymerase chain reaction.利用最小氨基酸序列和聚合酶链反应快速、选择性克隆监测肽,一种新型胆囊收缩素释放肽。
Pancreas. 1990;5(1):1-7. doi: 10.1097/00006676-199001000-00001.
7
Chronic ethanol consumption induces gene expression of pancreatic monitor peptide, but not SPINK1/PSTI-56, in rats.长期摄入乙醇可诱导大鼠胰腺监测肽的基因表达,但不诱导SPINK1/PSTI-56的基因表达。
Pancreas. 2001 Aug;23(2):117-24. doi: 10.1097/00006676-200108000-00001.
8
Monitor peptide gene expression is increased by exogenous CCK in the rat pancreas and in a rat pancreatic acinar cell line (AR4-2J).在大鼠胰腺和大鼠胰腺腺泡细胞系(AR4-2J)中,外源性胆囊收缩素可增加监测肽基因的表达。
FEBS Lett. 1992 Aug 3;307(3):386-8. doi: 10.1016/0014-5793(92)80719-w.
9
Elevation of circulating monitor peptide/pancreatic secretory trypsin inhibitor-I (PSTI-61) after turpentine-induced inflammation in rats: hepatocytes produce it as an acute phase reactant.
J Surg Res. 1994 Nov;57(5):563-8. doi: 10.1006/jsre.1994.1183.
10
Molecular cloning and nucleotide sequence of human pancreatic secretory trypsin inhibitor (PSTI) cDNA.人胰腺分泌型胰蛋白酶抑制剂(PSTI)cDNA的分子克隆及核苷酸序列
Biochem Biophys Res Commun. 1985 Oct 30;132(2):605-12. doi: 10.1016/0006-291x(85)91176-3.

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