肌腱蛋白-C在癌症中的诱导信号传导。

Tenascin-C induced signaling in cancer.

作者信息

Orend Gertraud, Chiquet-Ehrismann Ruth

机构信息

Department of Clinical and Biological Sciences, Institute of Biochemistry and Genetics, Center for Biomedicine, DKBW, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.

出版信息

Cancer Lett. 2006 Dec 8;244(2):143-63. doi: 10.1016/j.canlet.2006.02.017. Epub 2006 Apr 24.

DOI:10.1016/j.canlet.2006.02.017

PMID:16632194

Abstract

Tenascin-C is an adhesion modulatory extracellular matrix molecule that is highly expressed in the microenvironment of most solid tumors. High tenascin-C expression reduces the prognosis of disease-free survival in patients with some cancers. The possible role of tenascin-C in tumor initiation and progression is addressed with emphasis on underlying signaling mechanisms. How tenascin-C affects malignant transformation, uncontrolled proliferation, angiogenesis, metastasis and escape from tumor immunosurveillance is summarized. Finally, we discuss how the phenotypes of tenascin-C knock-out mice may help define the roles of tenascin-C in tumorigenesis and how this knowledge could be applied to cancer therapy.

摘要

腱生蛋白-C是一种调节黏附的细胞外基质分子，在大多数实体瘤的微环境中高度表达。腱生蛋白-C的高表达会降低某些癌症患者无病生存期的预后。本文着重探讨了腱生蛋白-C在肿瘤发生和进展中的可能作用及其潜在的信号传导机制。总结了腱生蛋白-C如何影响恶性转化、失控增殖、血管生成、转移以及肿瘤免疫逃逸。最后，我们讨论了腱生蛋白-C基因敲除小鼠的表型如何有助于确定腱生蛋白-C在肿瘤发生中的作用，以及这些知识如何应用于癌症治疗。