Alison Malcolm R, Lovell Matthew J, Direkze Natalie C, Wright Nicholas A, Poulsom Richard
Centre for Diabetes and Metabolic Medicine, Queen Mary' School of Medicine and Dentistry, Institute of Cell and Molecular Science, 4 Newark Street, Whitechapel, London E1 2AT, UK.
Eur J Cancer. 2006 Jun;42(9):1247-56. doi: 10.1016/j.ejca.2006.01.034. Epub 2006 May 2.
Stem cell plasticity refers to the ability of certain stem cells to switch lineage determination and generate unexpected cell types. This review applies largely to bone marrow cells (BMCs), which appear to contribute positively to the regeneration of several damaged non-haematopoietic tissues. This beneficial effect on regeneration may be a direct result of BMCs giving rise to organ parenchymal cells. Alternatively, it could be due to BMCs fusing with existing parenchymal cells, or providing paracrine growth factor support, or contributing to neovascularisation. In the context of oncology, BMC derivation of the tumour stroma and vasculature has profound biological and therapeutic implications, and there are several examples of carcinomas seemingly being derived from BMCs.
干细胞可塑性是指某些干细胞改变谱系决定并产生意外细胞类型的能力。本综述主要适用于骨髓细胞（BMCs），它们似乎对几种受损的非造血组织的再生有积极作用。这种对再生的有益影响可能是BMCs产生器官实质细胞的直接结果。或者，这可能是由于BMCs与现有的实质细胞融合，或提供旁分泌生长因子支持，或促进新血管形成。在肿瘤学背景下，肿瘤基质和脉管系统的BMC起源具有深远的生物学和治疗意义，并且有几个癌似乎起源于BMCs的例子。
