Direkze Natalie C, Alison Malcolm R
Histopathology Unit, Cancer Research, UK.
Hematol Oncol. 2006 Dec;24(4):189-95. doi: 10.1002/hon.788.
In recent years the bone marrow has become recognized as a potential source of cells for non-haematopoietic wound healing, in some instances demonstrating surprising plasticity in providing new epithelial cells. On the other hand, the contribution of bone marrow derived cells to fibrosis and blood vessel formation is more widely acknowledged. Tumour stroma has a vital role to play in determining cancer growth and spread, and there is a growing realization that the bone marrow has a significant input into this desmoplastic response. This review focuses on the contribution of bone marrow cells to tumour stroma, highlighting the bone marrow as a potential new portal through which to direct anti-tumour therapies.
近年来，骨髓已被公认为是用于非造血性伤口愈合的细胞潜在来源，在某些情况下，骨髓在提供新的上皮细胞方面展现出惊人的可塑性。另一方面，骨髓来源的细胞对纤维化和血管形成的作用得到了更广泛的认可。肿瘤基质在决定癌症的生长和扩散方面起着至关重要的作用，并且人们越来越认识到骨髓对这种促结缔组织增生反应有重大影响。本综述着重探讨骨髓细胞对肿瘤基质的作用，强调骨髓是一个潜在的新靶点，可通过它来指导抗肿瘤治疗。
