Andzé G O, Luks F I, Bensoussan A L, Blanchard H
Département de chirurgie, hôpital Sainte-Justine, université de Montréal, Québec, Canada.
Pediatrie. 1991;46(5):451-4.
The relationship between gastro-esophageal reflux (GER) and asthma, and the role of treatment of this disorder in severe asthma cases remain ill-defined. Using esophageal pH monitoring, pathological GER was demonstrated in 57 of 139 children with severe asthma. Among these 57 patients medical treatment of GER lessened the respiratory symptoms in 24 and was without effect in 33. In the latter group, asthma was improved in 29 with surgical treatment of the GER, the results being less satisfactory in those patients without GER digestive symptoms. Our results suggest that there is a place for treatment of GER in selected children with severe asthma. Esophageal pH monitoring appears useful to detect pathological GER and to determine which patients may benefit from surgical treatment.
胃食管反流（GER）与哮喘之间的关系，以及这种病症的治疗在重度哮喘病例中的作用仍不明确。通过食管pH监测，在139例重度哮喘患儿中有57例证实存在病理性GER。在这57例患者中，GER的药物治疗使24例患者的呼吸道症状减轻，33例无效。在后一组中，29例GER手术治疗后哮喘得到改善，而那些没有GER消化系统症状的患者结果不太令人满意。我们的结果表明，在部分重度哮喘患儿中GER治疗有其适用之处。食管pH监测似乎有助于检测病理性GER并确定哪些患者可能从手术治疗中获益。
