Ruiz Tovar J, Reguero Callejas M E, Arano Bermejo J I, Capote Armas L F, González-Palacios Martínez F, Cabañas Navarro L
Department of General Surgery and Digestive System, University Hospital Ramón y Cajal, Madrid, Spain.
Clin Transl Oncol. 2006 Feb;8(2):129-32. doi: 10.1007/s12094-006-0170-1.
Malignant mixed Mullerian tumours (MMMTs) are rare neoplasms, highly aggressive and with an extremely poor prognosis, usually arising in elderly postmenopausal women and presenting at an advanced stage. MMMTs derive from the mullerian mesodermus that differentiates in epithelial and stromal elements, both malignant elements. The clinic pathological features of 3 uterine MMMTs are reported here. The patients ranged in age from 25 to 69 years. The initial manifestations were mainly bloody discharge, abdominal pain and increase of the volume of the uterus. Treatment in 2 patients was hysterectomy with double ooforectomy, and resection of the pelvic mass was the treatment in the third case. Adjuvant radio chemotherapy was administrated in 2 of the 3 cases. Follow-up revealed recurrent pelvic tumour in 1 patient at 59 months, and breast metastases at 20 months in the second one. Because of the high incidence of recurrence and poor prognosis of these tumours, they should be studied and managed by a multidisciplinary team composed by surgeons, oncologists, radiotherapists and pathologists.
恶性苗勒管混合瘤（MMMTs）是罕见肿瘤，侵袭性强，预后极差，通常发生于绝经后老年女性，且就诊时多为晚期。MMMTs起源于苗勒中胚层，可分化为上皮和间质成分，二者均为恶性成分。本文报告3例子宫MMMTs的临床病理特征。患者年龄在25至69岁之间。初始表现主要为血性分泌物、腹痛和子宫体积增大。2例患者接受了子宫切除术加双侧卵巢切除术，第3例患者接受了盆腔肿块切除术。3例中有2例接受了辅助放化疗。随访发现，1例患者在59个月时盆腔肿瘤复发，另1例在20个月时出现乳腺转移。由于这些肿瘤复发率高且预后差，应由外科医生、肿瘤学家、放疗科医生和病理学家组成的多学科团队对其进行研究和管理。
