两种新型血管紧张素转换酶抑制剂的合成及抗酶活性
Synthesis and antienzymic activity of two new angiotensin converting enzyme inhibitors.
作者信息
Dudkiewicz J, Suska T, Tautt J, Paruszewski R
机构信息
Institute for Drug Research and Control, Warszawa, Poland.
出版信息
Pol J Pharmacol Pharm. 1991 Jan-Feb;43(1):33-8.
PMID:1663247
Abstract
Two new analogs of captopril were synthesized. Inhibition of angiotensin converting enzyme (ACE) by these compounds in vitro and in vivo was determined using fluorimetric method. The obtained compounds were much weaker ACE inhibitors than captopril.
摘要
合成了两种新的卡托普利类似物。使用荧光法测定了这些化合物在体外和体内对血管紧张素转换酶（ACE）的抑制作用。所得到的化合物作为ACE抑制剂的活性比卡托普利弱得多。
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