Vernigora A N, Gengin M T, Nikishin N N, Shchetinina N V
Vopr Med Khim. 1996 Jan-Mar;42(1):34-8.
Captopril was investigated for its effects on the activity of angiotensin-converting enzyme in the rat blood serum, pituitary, hypothalamus, and striatum, as well as for those on the animals, behavior in the open-field test. During its single administration the agent was found to lower the activity of angiotensin-converting enzyme in all the examined brain regions and serum. During chronic administration captopril decreased the mobility of the animals in the open-field test, diminished, the activity of the enzyme in the hypothalamus and striatum and enhanced it in the pituitary and serum. It is suggested that the effect of captopril might be due to imbalance in the changes of angiotensin-converting enzyme activity in various brain regions of the rats.
研究了卡托普利对大鼠血清、垂体、下丘脑和纹状体中血管紧张素转换酶活性的影响，以及对动物在旷场试验中行为的影响。单次给药时，发现该药物可降低所有检测脑区和血清中血管紧张素转换酶的活性。长期给药时，卡托普利降低了动物在旷场试验中的活动能力，降低了下丘脑和纹状体中酶的活性，并提高了垂体和血清中的酶活性。提示卡托普利的作用可能是由于大鼠不同脑区血管紧张素转换酶活性变化失衡所致。
