Walsh A E, Ware C J, Cowen P J
MRC Unit of Clinical Pharmacology, Littlemore Hospital, Oxford, UK.
Psychopharmacology (Berl). 1991;105(4):568-72. doi: 10.1007/BF02244382.
The effect of lithium administration (800 mg daily for 7 days) on the neuroendocrine and temperature responses to the 5-HT1A receptor agonist, gepirone, was studied in eight healthy male volunteers. Gepirone (20 mg orally) significantly increased plasma levels of prolactin, growth hormone, corticotropin and cortisol, and lowered oral temperature. None of these responses was significantly altered by lithium treatment. The results suggest that the ability of short-term lithium treatment to increase 5-HT-mediated neuroendocrine responses in humans is unlikely to be related to changes in the sensitivity of pre- or post-synaptic 5-HT1A receptors.
在8名健康男性志愿者中研究了锂剂给药（每日800毫克，共7天）对5-羟色胺1A（5-HT1A）受体激动剂吉哌隆的神经内分泌及体温反应的影响。吉哌隆（口服20毫克）显著升高了催乳素、生长激素、促肾上腺皮质激素和皮质醇的血浆水平，并降低了口腔温度。锂剂治疗并未显著改变这些反应。结果表明，短期锂剂治疗增加人类5-羟色胺介导的神经内分泌反应的能力不太可能与突触前或突触后5-HT1A受体敏感性的变化有关。
