Anderson I M, Cowen P J, Grahame-Smith D G
MRC Unit of Clinical Pharmacology, Littlemore Hospital, Oxford, UK.
Psychopharmacology (Berl). 1990;100(4):498-503. doi: 10.1007/BF02244002.
The effects of the selective 5-HT1A receptor agonist gepirone (10 and 20 mg orally) on neuroendocrine function and temperature were assessed using a single-blind cross-over design in 12 healthy male volunteers. Gepirone significantly increased plasma levels of ACTH, beta-endorphin, cortisol, prolactin and growth hormone. Following gepirone there was a significant decrease in body temperature and moderate increases in subjective reports of light-headedness, nausea and drowsiness. Our results are consistent with studies in rodents suggesting that 5-HT1A receptor agonists increase ACTH and prolactin secretion and decrease body temperature. Further investigations are needed to determine if the neuroendocrine and temperature effects of gepirone in humans are mediated by 5-HT1A receptors.
采用单盲交叉设计，在12名健康男性志愿者中评估了选择性5-HT1A受体激动剂吉哌隆（口服10毫克和20毫克）对神经内分泌功能和体温的影响。吉哌隆显著提高了促肾上腺皮质激素、β-内啡肽、皮质醇、催乳素和生长激素的血浆水平。服用吉哌隆后，体温显著下降，头晕、恶心和嗜睡的主观报告有中度增加。我们的结果与啮齿动物研究一致，表明5-HT1A受体激动剂可增加促肾上腺皮质激素和催乳素分泌并降低体温。需要进一步研究以确定吉哌隆在人体中的神经内分泌和体温效应是否由5-HT1A受体介导。
