Ritterband David C, Seedor John A, Shah Mahendra K, Koplin Richard S, McCormick Steven A
Department of Ophthalmology, New York Eye and Ear Infirmary, New York, NY 10003, USA.
Cornea. 2006 Apr;25(3):264-7. doi: 10.1097/01.ico.0000177423.77648.8d.
This study was designed to review the clinical experience at our institution with fungal keratitis during a 16-year period.
A review of the clinical and microbiology records of the New York Eye and Infirmary identified 61cases of fungal keratitis in 57 patients between January 1, 1987 and June 1, 2003. The medical records of all patients were retrospectively reviewed to better delineate patient demographics, risk factors, etiologic organisms, treatment, and outcomes.
A total of 5083 positive corneal cultures were recorded'from January 1, 1987 to June 1, 2003. Sixty-one eyes in 57 patients (37 women) were positive for fungus (1.2%). Three'patients had bilateral simultaneous infections. Candida albicans accounted for 29 of 61 cases (48%). Human immunodeficiency virus (HIV) seropositivity (15 eyes), chronic ocular surface disease (14 eyes), and trauma (7 eyes) were the most commonly associated risk factors.
Our experience with fungal keratitis in the northeastern United States appears to be different than those reported from other areas of the United States. Serologic positivity for HIV and chronic ocular surface disease were the most common associated risk factors followed by trauma, herpes simplex keratitis, and contact lens use. Candida species predominated, whereas filamentous fungi were uncommon.
本研究旨在回顾我院16年间真菌性角膜炎的临床经验。
回顾纽约眼耳医院的临床和微生物学记录，确定了1987年1月1日至2003年6月1日期间57例患者中的61例真菌性角膜炎病例。对所有患者的病历进行回顾性分析，以更好地描述患者的人口统计学特征、危险因素、病原体、治疗方法及预后。
1987年1月1日至2003年6月1日期间共记录了5083份阳性角膜培养物。57例患者（37名女性）中的61只眼真菌检测呈阳性（1.2%）。3例患者为双侧同时感染。白色念珠菌占61例中的29例（48%）。人类免疫缺陷病毒（HIV）血清学阳性（15只眼）、慢性眼表疾病（14只眼）和外伤（7只眼）是最常见的相关危险因素。
我们在美国东北部真菌性角膜炎方面的经验似乎与美国其他地区报道的不同。HIV血清学阳性和慢性眼表疾病是最常见的相关危险因素，其次是外伤、单纯疱疹性角膜炎和隐形眼镜使用。念珠菌属占主导，而丝状真菌并不常见。
