Stimac Davor, Fisić Elizabeta, Milić Sandra, Bilić-Zulle Lidija, Perić Relja
Division of Gastroenterology, Department of Internal Medicine, Clinical Hospital Center Rijeka, Rijeka, Croatia.
J Clin Gastroenterol. 2006 Mar;40(3):209-12. doi: 10.1097/00004836-200603000-00007.
The prognostic importance of interleukin-6 (IL-6), IL-8, and IL-10 in the prediction of acute pancreatitis severity.
Early assessment of severity in acute pancreatitis could help the patients who are at risk of developing complications. Unfortunately, the used prognostic scoring systems generally are only moderately accurate in assessing disease severity.
We studied 117 consecutive patients with a diagnosis of acute pancreatitis admitted to our hospital during the past 2 years. Laboratory parameters and cytokines were analyzed from serum taken routinely on admission. Severity criteria were noted for each patient using Ranson, Glasgow, and APACHE II scoring systems. Local and systemic complications, developed during a follow-up period, were classified by Atlanta criteria.
IL-6 was the only parameter that statistically significantly predicted complicated acute pancreatitis (P<0.05). IL-8 and IL-10 and the 3 prognostic scoring systems used did not properly assess complicated versus noncomplicated acute pancreatitis.
Our prospective study supported the potential importance of IL-6 in the early assessment of complicated acute pancreatitis, but also suggested that pancreatitis classified as complicated in a large number of patients could not be correctly predicted with the Ranson, Glasgow, and APACHE II scoring systems.
白细胞介素-6（IL-6）、IL-8和IL-10在预测急性胰腺炎严重程度方面的预后重要性。
急性胰腺炎严重程度的早期评估有助于识别有发生并发症风险的患者。不幸的是，目前使用的预后评分系统在评估疾病严重程度时通常准确性仅为中等。
我们研究了过去2年中我院收治的117例连续诊断为急性胰腺炎的患者。分析入院时常规采集血清中的实验室参数和细胞因子。使用兰森（Ranson）、格拉斯哥（Glasgow）和急性生理与慢性健康状况评分系统II（APACHE II）对每位患者的严重程度标准进行记录。随访期间发生的局部和全身并发症按照亚特兰大标准进行分类。
IL-6是唯一在统计学上显著预测复杂性急性胰腺炎的参数（P<0.05）。IL-8、IL-10以及所使用的3种预后评分系统均不能准确评估复杂性与非复杂性急性胰腺炎。
我们的前瞻性研究支持了IL-6在早期评估复杂性急性胰腺炎方面的潜在重要性，但也表明大量被归类为复杂性胰腺炎的患者无法通过兰森、格拉斯哥和APACHE II评分系统正确预测。
