The Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China.
The First Clinical Medical College, Lanzhou University, Lanzhou 730030, China.
Biomolecules. 2024 Sep 2;14(9):1101. doi: 10.3390/biom14091101.
Acute pancreatitis remains a serious public health problem, and the burden of acute pancreatitis is increasing. With significant morbidity and serious complications, appropriate and effective therapies are critical. Great progress has been made in understanding the pathophysiology of acute pancreatitis over the past two decades. However, specific drugs targeting key molecules and pathways involved in acute pancreatitis still require further study. Natural compounds extracted from plants have a variety of biological activities and can inhibit inflammation and oxidative stress in acute pancreatitis by blocking several signaling pathways, such as the nuclear factor kappa-B and mitogen-activated protein kinase pathways. In this article, we review the therapeutic effects of various types of phytochemicals on acute pancreatitis and discuss the mechanism of action of these natural compounds in acute pancreatitis, aiming to provide clearer insights into the treatment of acute pancreatitis.
急性胰腺炎仍然是一个严重的公共卫生问题，而且急性胰腺炎的负担正在增加。由于发病率高且并发症严重，因此适当和有效的治疗方法至关重要。在过去的二十年中，人们对急性胰腺炎的病理生理学有了重大的认识。然而，针对急性胰腺炎中涉及的关键分子和途径的特定药物仍需要进一步研究。从植物中提取的天然化合物具有多种生物活性，通过阻断核因子 kappa-B 和丝裂原活化蛋白激酶等多种信号通路，可以抑制急性胰腺炎中的炎症和氧化应激。本文综述了各种植物化学物质对急性胰腺炎的治疗作用，并探讨了这些天然化合物在急性胰腺炎中的作用机制，旨在为急性胰腺炎的治疗提供更清晰的思路。
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