Berman D E, Lettieri J, Herold D A, Lin Y F, Morgan R F
Department of Plastic Surgery, Medical University, Spartanburg, SC.
Ann Plast Surg. 1991 Oct;27(4):316-20. doi: 10.1097/00000637-199110000-00005.
The rate of diffusion of benzyl alcohol (the bacteriostatic agent in the provided diluent) and methylprednisolone 21-hemisuccinate and related rearrangement and hydrolysis products ("steroid") through tissue expanders was examined. The rate of diffusion of steroid through double lumen breast implants was also studied. It was found that benzyl alcohol rapidly diffused through tissue expanders into a saline bath. By 24 hours, one-half of the benzyl alcohol had diffused through the expander. The steroid was much slower to diffuse out of the expander. By 141 days, only 2% of the steroid was found in the bath. This rate was comparable for both the tissue expander and double lumen implants. In addition, a significant amount of the steroid is located in the expander wall, associated with the surface of the expander or precipitated out of solution or both. The clinical significance of these findings is discussed.
研究了苄醇（所提供稀释剂中的抑菌剂）、甲泼尼龙21-半琥珀酸酯及相关重排和水解产物（“类固醇”）通过组织扩张器的扩散速率。还研究了类固醇通过双腔乳房植入物的扩散速率。结果发现，苄醇迅速通过组织扩张器扩散到盐浴中。到24小时时，一半的苄醇已扩散通过扩张器。类固醇从扩张器中扩散出来的速度要慢得多。到141天时，在浴中仅发现2%的类固醇。组织扩张器和双腔植入物的这个速率相当。此外，大量的类固醇位于扩张器壁中，与扩张器表面相关联或从溶液中沉淀出来或两者皆有。讨论了这些发现的临床意义。
