Berman D E, Lettieri J, Herold D A, Thorne J, Morgan R F
Department of Plastic Surgery, Medical University, Spartanburg, SC.
Ann Plast Surg. 1991 Oct;27(4):312-5. doi: 10.1097/00000637-199110000-00004.
Previous work in our laboratory has demonstrated that tissue expanders are permeable to lidocaine. In this two-part study, we assessed the in vitro lidocaine diffusion in the following five common tissue expanders: Dow Corning, McGhan, Cox-Uphoff, Hyer-Schulte (Mentor), and Surgitek. In part 1, we demonstrated that wall thickness appeared to be the major determinant for diffusion. Part 2 reports an in vivo study of lidocaine diffusion from tissue expanders used for breast reconstruction. We initially determined that there is incomplete mixing between the valve and connecting tubing and the contents of the expanders, over the period of 1 week. We subsequently examined the lidocaine diffusion from seven tissue expanders placed in a submuscular position for breast reconstruction. The rate of lidocaine diffusion was highly variable, but on average was about 3% per day.
我们实验室之前的研究表明，组织扩张器可透过利多卡因。在这项分为两部分的研究中，我们评估了以下五种常见组织扩张器中利多卡因的体外扩散情况：道康宁（Dow Corning）、麦加恩（McGhan）、考克斯 - 乌霍夫（Cox-Uphoff）、海尔 - 舒尔特（海厄 - 舒尔特，Mentor）和苏格泰克（Surgitek）。在第一部分中，我们证明壁厚似乎是扩散的主要决定因素。第二部分报告了一项关于用于乳房重建的组织扩张器中利多卡因扩散的体内研究。我们最初确定，在1周的时间里，阀门和连接管与扩张器内容物之间存在不完全混合。随后，我们检查了放置在胸肌下用于乳房重建的七个组织扩张器中利多卡因的扩散情况。利多卡因的扩散速率变化很大，但平均每天约为3%。
