Alibert Sophie, Gérolami René, Tammam David, Borentain Patrick, Tissot-Dupont Hervé, Zandotty Christine, Hardwigsen Jean, Stefaniescu Mona, Barrantes Carlos, Le Treut Yves-Patrice, Botta-Fridlund Danièle
Service d'Hépato-Gastroentérologie, Hôpital de la Conception, Marseille.
Gastroenterol Clin Biol. 2006 Mar;30(3):473-5. doi: 10.1016/s0399-8320(06)73206-7.
Progressive multifocal leucoencephalopathy due to JC virus is a rare complication of liver transplantation. Only four cases have already been described in the literature. This disease is difficult to differentiate from leucoencephalopathy associated with immunosuppressive drugs such as cyclosporin or tacrolimus. Positive diagnosis of progressive multifocal leucoencephalopathy no longer requires cerebral biopsy. It must be confirmed by positive JC virus RNA amplification in the cerebrospinal fluid. We report a case of progressive multifocal leucoencephalopathy occurring 18 months after liver transplantation for hepatitis C-related cirrhosis.
由JC病毒引起的进行性多灶性白质脑病是肝移植的一种罕见并发症。文献中仅描述了4例。这种疾病很难与环孢素或他克莫司等免疫抑制药物相关的白质脑病相鉴别。进行性多灶性白质脑病的阳性诊断不再需要脑活检。必须通过脑脊液中JC病毒RNA扩增阳性来确诊。我们报告1例丙型肝炎相关肝硬化肝移植术后18个月发生进行性多灶性白质脑病的病例。
