D'Souza-Schorey Crislyn, Chavrier Philippe
Department of Biological Sciences and the Walther Cancer Institute, University of Notre Dame, Notre Dame, Indiana, USA.
Nat Rev Mol Cell Biol. 2006 May;7(5):347-58. doi: 10.1038/nrm1910.
The ADP-ribosylation factor (ARF) small GTPases regulate vesicular traffic and organelle structure by recruiting coat proteins, regulating phospholipid metabolism and modulating the structure of actin at membrane surfaces. Recent advances in our understanding of the signalling pathways that are regulated by ARF1 and ARF6, two of the best characterized ARF proteins, provide a molecular context for ARF protein function in fundamental biological processes, such as secretion, endocytosis, phagocytosis, cytokinesis, cell adhesion and tumour-cell invasion.
ADP核糖基化因子（ARF）小GTP酶通过招募衣被蛋白、调节磷脂代谢以及调节膜表面肌动蛋白的结构来调控囊泡运输和细胞器结构。在我们对ARF1和ARF6这两种特征最为明确的ARF蛋白所调控的信号通路的理解方面，最近取得的进展为ARF蛋白在诸如分泌、内吞作用、吞噬作用、胞质分裂、细胞黏附和肿瘤细胞侵袭等基本生物学过程中的功能提供了分子背景。
