Abdulkareem F B, Banjo A A F, Elesha S O, Daramola A O
Department of Morbid Anatomy, College of Medicine of the University of Lagos, Idi-Araba, P. M. B. 12003, Surulere, Lagos, Nigeria.
Niger Postgrad Med J. 2006 Mar;13(1):41-6.
We present a retrospective histopathological study of 345 liver biopsies over a 12-year period. The study sought to record the frequencies of the range of histopathological changes observed in liver biopsy specimens.
the materials consisted of slides and paraffin embedded blocks of all liver biopsy specimens received from within and outside the hospital. The clinical data such as the age, sex, and clinical summary were extracted from the request forms.
there were 222 males and 123 females; M: F=1.8:1; peak age incidence of 41-50 years. The three common histopathological diagnoses were hepatocellular carcinoma-33%, chronic hepatitis-17.7%, and liver cirrhosis-17.7%. Thirty per cent of hepatocellular carcinoma was post-cirrhotic. The peak age incidence of chronic hepatitis precedes that of liver cirrhosis and hepatocellular carcinoma by one decade.
the common forms of liver disease diagnosed histologically are hepatocellular carcinoma, chronic hepatitis and liver cirrhosis. The age and sex distribution are similar to those already established in the African literature.
我们对12年间的345例肝脏活检进行了回顾性组织病理学研究。该研究旨在记录肝脏活检标本中观察到的组织病理学变化范围的频率。
材料包括从医院内外接收的所有肝脏活检标本的玻片和石蜡包埋块。从申请表格中提取年龄、性别和临床摘要等临床数据。
男性222例，女性123例；男：女 = 1.8:1；发病高峰年龄为41 - 50岁。三种常见的组织病理学诊断为肝细胞癌 - 33%，慢性肝炎 - 17.7%，肝硬化 - 17.7%。30%的肝细胞癌发生在肝硬化之后。慢性肝炎的发病高峰年龄比肝硬化和肝细胞癌早十年。
组织学诊断的常见肝病形式为肝细胞癌、慢性肝炎和肝硬化。年龄和性别分布与非洲文献中已确定的相似。
