Anunobi C C, Akinsola F B, Abdulkareem F B, Aribaba O T, Nnoli M A, Banjo A A F
Department of Histopathology and Morbid Anatomy, Lagos University Teaching Hospital and the College of Medicine, University of Lagos.
Niger Postgrad Med J. 2008 Sep;15(3):146-51.
we present a 10year retrospective clinicopathologic study of 135 cases of orbito-ocular lesions. The aim is to document pattern of orbito-ocular lesions, with their site, age and sex distribution.
The materials consisted of slides, paraffin embedded tissue blocks and histology request forms of all orbito-ocular samples received at the Morbid Anatomy Department of Lagos University Teaching Hospital Idi-Araba Lagos between 1994 and 2003.
A total of 135 samples from 75(56%) males and 60(44%) females were analysed. The conjunctival, intraocular, orbital and eye lid lesions accounted for 27(20.1%), 75(55.5%), 18(13.4%) and 15(11%) cases respectively. The ages ranged from 20 days to 79 years with a mean age of 35 years. Sixty nine cases (51.1%) of all orbito-ocular lesions were seen in children of age 15 years and below. Squamous cell carcinoma was the commonest malignant conjunctival lesion (4 out of the 5 cases) occurring in adults with a mean age of 45 years. Retinoblastoma accounted for 46(85%) of all orbito-ocular malignancies with the peak in the 1-5year age group accounting for 37(80 %). Panophthalmitis, endophthalmitis and phthisis bulbi were common non neoplastic lesions requiring enucleation. Pseudotumour and rhabdomyosarcoma accounted for 5(27.8 %) and 4(22.2 %) cases respectively of all orbital lesions.
Retinoblastoma remains the commonest ocular malignancy while rhabdomyosarcoma was the commonest orbital malignancy with both occurring in childhood. Inflammatory lesions unfortunately are important orbito-ocular lesions requiring surgery in our environment.
我们对135例眼眶-眼部病变进行了为期10年的回顾性临床病理研究。目的是记录眼眶-眼部病变的模式及其部位、年龄和性别分布。
材料包括1994年至2003年期间在拉各斯大学教学医院伊迪-阿拉巴分校病理解剖科接收的所有眼眶-眼部样本的玻片、石蜡包埋组织块和组织学申请表。
共分析了135个样本，其中男性75例（56%），女性60例（44%）。结膜、眼内、眼眶和眼睑病变分别占27例（20.1%）、75例（55.5%）、18例（13.4%）和15例（11%）。年龄范围从20天至79岁，平均年龄为35岁。15岁及以下儿童中出现了69例（51.1%）所有眼眶-眼部病变。鳞状细胞癌是最常见的成人结膜恶性病变（5例中有4例），平均年龄为45岁。视网膜母细胞瘤占所有眼眶-眼部恶性肿瘤的46例（85%），1-5岁年龄组发病率最高，占37例（80%）。全眼球炎、眼内炎和眼球痨是需要摘除眼球的常见非肿瘤性病变。假瘤和横纹肌肉瘤分别占所有眼眶病变的5例（27.8%）和4例（22.2%）。
视网膜母细胞瘤仍然是最常见的眼部恶性肿瘤，而横纹肌肉瘤是最常见的眼眶恶性肿瘤，两者均发生于儿童期。不幸的是，在我们所处的环境中，炎性病变是需要手术治疗的重要眼眶-眼部病变。
