精神障碍中的基因-环境相互作用。
Gene-environment interactions in mental disorders.
作者信息
Tsuang Ming T, Bar Jessica L, Stone William S, Faraone Stephen V
机构信息
Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, Boston, MA 02115, USA.
出版信息
World Psychiatry. 2004 Jun;3(2):73-83.
Abstract
Research clearly shows that both nature and nurture play important roles in the genesis of psychopathology. In this paper, we focus on 'gene-environment interaction' in mental disorders, using genetic control of sensitivity to the environment as our definition of that term. We begin with an examination of methodological issues involving gene-environment interactions, with examples concerning psychiatric and neurological conditions. Then we review the interactions in psychiatric disorders using twin, adoption and association designs. Finally, we consider gene-environment interactions in selected neurodevelopmental disorders (autism and schizophrenia).
摘要
研究清楚地表明，先天因素和后天培养在精神病理学的发生过程中都起着重要作用。在本文中，我们聚焦于精神障碍中的“基因-环境相互作用”，将对环境敏感性的遗传控制作为该术语的定义。我们首先考察涉及基因-环境相互作用的方法学问题，并列举有关精神疾病和神经疾病的实例。然后，我们使用双生子、收养和关联设计来回顾精神障碍中的相互作用。最后，我们思考特定神经发育障碍（自闭症和精神分裂症）中的基因-环境相互作用。
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