Ozmen Ozlem, Tasan Serife, Unal Gulin Ozdamar
Burdur Mehmet Akif Ersoy University - Department of Pathology, Burdur - Turquia.
Suleyman Demirel University - Department of Psychiatry, Isparta - Turquia.
Arq Bras Cardiol. 2025 Feb 10;122(2):e20240159. doi: 10.36660/abc.20240159. eCollection 2025.
Stress arises in response to threats or challenges, affecting both physical and mental health. While its harmful effects on the heart are widely recognized, cellular-level investigations remain limited. Antidepressants, including vortioxetine (VOR), are known to impact the cardiovascular system. VOR, used to treat major depressive disorder, is considered a promising option for patients with heart disease due to its anti-inflammatory and antioxidant properties, which may reduce cardiac damage.
This study aimed to assess the effects of chronic unpredictable mild stress (CUMS) on rat hearts and evaluate VOR's potential protective effects against stress-induced cardiac damage.
Twenty-eight male Wistar Albino rats were divided into four groups. The CUMS group experienced random daily stress for 6 weeks, while the CUMS+VOR group received VOR treatment alongside stress. VOR and control groups were not exposed to stress. Heart samples were examined histopathologically and immunohistochemically.
The CUMS group showed increased hyperemia, hemorrhage, edema, vacuolar degeneration, and mononuclear cell infiltrations, with reduced troponin and IL-10 and increased caspase-3 and NF-κB expressions compared to the control group (p≤0.001). VOR treatment improved these findings, normalizing histopathological and immunohistochemical results.
CUMS caused significant cardiac damage in rats, while VOR treatment showed protective effects by alleviating these pathological changes.
压力是对威胁或挑战的反应，会影响身心健康。虽然其对心脏的有害影响已广为人知，但细胞水平的研究仍然有限。包括伏硫西汀（VOR）在内的抗抑郁药已知会影响心血管系统。用于治疗重度抑郁症的VOR，因其具有抗炎和抗氧化特性，可能减少心脏损伤，被认为是心脏病患者的一个有前景的选择。
本研究旨在评估慢性不可预测轻度应激（CUMS）对大鼠心脏的影响，并评估VOR对应激诱导的心脏损伤的潜在保护作用。
将28只雄性Wistar白化大鼠分为四组。CUMS组每天经历随机应激6周，而CUMS + VOR组在应激的同时接受VOR治疗。VOR组和对照组未暴露于应激。对心脏样本进行组织病理学和免疫组织化学检查。
与对照组相比，CUMS组出现充血、出血、水肿、空泡变性和单核细胞浸润增加，肌钙蛋白和IL-10减少，caspase-3和NF-κB表达增加（p≤0.001）。VOR治疗改善了这些结果，使组织病理学和免疫组织化学结果正常化。
CUMS在大鼠中引起了显著的心脏损伤，而VOR治疗通过减轻这些病理变化显示出保护作用。
