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Quantification of ion-induced molecular fragmentation of isolated 2-deoxy-D-ribose molecules.

作者信息

Alvarado Fresia, Bari Sadia, Hoekstra Ronnie, Schlathölter Thomas

机构信息

KVI Atomic Physics, Rijksuniversiteit Groningen, Zernikelaan 25, NL-9747AA, Groningen, The Netherlands.

出版信息

Phys Chem Chem Phys. 2006 Apr 28;8(16):1922-8. doi: 10.1039/b517109a. Epub 2006 Mar 14.

DOI:10.1039/b517109a
PMID:16633679
Abstract

Recent experiments on low energy ion-induced damage to DNA building blocks indicate that ion induced DNA damage is dominated by deoxyribose disintegration (Phys. Rev. Lett., 2005, 95, 153201). We have studied interactions of keV H+ and He(q+) with isolated deoxyribose molecules by means of high resolution time-of-flight spectrometry. Extensive statistical fragmentation of the molecules is observed. The fragment distribution is found to follow a power law dependence. The exponent can be used to characterize and quantify the molecular damage.

摘要

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