Sánchez Eduardo, Barro Senén, Mariño Jorge, Canedo Antonio
Grupo de Sistemas Intelixentes (GSI), Departamento de Electrónica e computación, Facultade de Físicas, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
J Comput Neurosci. 2006 Aug;21(1):21-33. doi: 10.1007/s10827-006-7058-5. Epub 2006 Apr 22.
We present a computational study aimed at exploring the sensorimotor cortex modulation of the behaviour of dorsal column nuclei, specifically the impact of synaptic parameters, during both sleep and waking conditions. On the basis of the circuit proposed by Canedo et al. (2000), we have developed realistic computational models that have been tested with simultaneous electrocorticographic as well as intracellular cuneate recordings performed in anaesthetized cats. The results show that, (1) under sleep conditions, the model can block the transmission of afferent sensory information and, (2) operations expected during wakefulness, such as filtering and facilitation, can be performed if synaptic parameters are appropriately tuned.
我们开展了一项计算研究，旨在探究睡眠和清醒状态下，感觉运动皮层对背柱核行为的调节作用，特别是突触参数的影响。基于卡内多等人（2000年）提出的神经回路，我们开发了逼真的计算模型，并在麻醉猫身上同时进行了皮层脑电图和楔束核细胞内记录测试。结果表明：（1）在睡眠状态下，该模型能够阻断传入感觉信息的传递；（2）如果对突触参数进行适当调整，清醒时预期的操作（如过滤和易化）即可实现。
