Aupperle Peter
Division of Geriatric Psychiatry, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA.
Am J Alzheimers Dis Other Demen. 2006 Mar-Apr;21(2):101-8. doi: 10.1177/153331750602100209.
The behavioral and psychological symptoms of dementia (BPSD), such as psychosis, agitation, or aggression have a considerable negative impact on the quality of life of both patients and their caregivers. Multiple studies have demonstrated that atypical antipsychotics are efficacious in the treatment of the aggressive and psychotic symptom clusters, and here we review their use in this indication. Because of the safety concerns associated with the use of atypical antipsychotics in this population, these drugs must be used judiciously. For patients with severe BPSD such as psychosis, agitation, or aggression, for whom there are few options, atypical antipsychotics, particularly risperidone and olanzapine, should be considered.
痴呆的行为和心理症状（BPSD），如精神病、激越或攻击行为，对患者及其照护者的生活质量都有相当大的负面影响。多项研究表明，非典型抗精神病药物在治疗攻击和精神病症状群方面有效，在此我们综述其在这一适应症中的应用。由于在该人群中使用非典型抗精神病药物存在安全问题，这些药物必须谨慎使用。对于患有严重BPSD（如精神病、激越或攻击行为）且选择有限的患者，应考虑使用非典型抗精神病药物，尤其是利培酮和奥氮平。
