阿尔茨海默病的识别与治疗：基于病例的综述
Recognition and treatment of Alzheimer's disease: a case-based review.
作者信息
Marseille Dana M, Silverman Daniel H S
机构信息
Neuronuclear Imaging Section, Division of Biological Imaging, David Geffen School of Medicine, University of California at Los Angeles Medical Center, Los Angeles, California, USA.
出版信息
Am J Alzheimers Dis Other Demen. 2006 Mar-Apr;21(2):119-25. doi: 10.1177/153331750602100212.
Early recognition and treatment initiation are pivotal in managing Alzheimer's disease (AD). Once a diagnosis of AD is made, a treatment plan is developed and should include treatment initiation with cholinesterase inhibitors (ChEIs) to improve cognition, management of comorbid conditions, and treat behavioral symptoms. Caregiver compliance is integral to AD treatment success. The purpose of this report is to present two real case studies of "suspected" AD or related dementia and stress the significance of early and accurate diagnosis in disease management. In case 1, a caregiver reports gradual but progressive loss of memory, and the patient himself complains of memory impairment. Neuroimaging analysis confirms "typical " AD. In case 2, initiation of ChEI therapy is followed by substantial clinical improvement in the face of a complex medical picture, and neuroimaging revealing more neurodegenerative changes than could be accounted for by "pure" AD.
早期识别和开始治疗对于阿尔茨海默病（AD）的管理至关重要。一旦确诊为AD，就要制定治疗计划，该计划应包括使用胆碱酯酶抑制剂（ChEIs）开始治疗以改善认知、管理合并症以及治疗行为症状。照顾者的依从性是AD治疗成功的关键。本报告的目的是呈现两个“疑似”AD或相关痴呆的真实病例研究，并强调早期准确诊断在疾病管理中的重要性。在病例1中，一位照顾者报告患者记忆力逐渐但呈进行性丧失，患者本人也抱怨有记忆障碍。神经影像学分析确诊为“典型”AD。在病例2中，面对复杂的病情，开始使用ChEI治疗后临床症状有显著改善，神经影像学显示神经退行性变化比“单纯”AD所能解释的更多。
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