Cortes Frédéric, Gillette-Guyonnet Sophie, Nourhashemi Fati, Christelle Cantet, Vellas Bruno
Service de Médecine Interne et Gérontologie Clinique, Toulouse, France.
Am J Alzheimers Dis Other Demen. 2006 Mar-Apr;21(2):131-6. doi: 10.1177/153331750602100214.
The purpose of this study was to determine whether a family history of dementia in a first-degree relative influenced the progression of Alzheimer's disease (AD) after two years of follow-up. Patients were recruited in the REAL.FR (Réseau sur la Maladie d'Alzheimer Français) study and underwent behavioral, global, nutritional, and medical evaluation with assessment of cognitive function and independence every six months. At inclusion, 113 patients reported a family history of dementia, and 358 patients had no family history of dementia. There was no statistical difference for any factors between the two groups at baseline. After two years of follow-up, a similar percentage of patients were still followed in each group, and although most parameters showed significant deterioration, there was no difference between the two groups, indicating that a family history of dementia does not appear to influence the progression of AD.
本研究的目的是确定在随访两年后，一级亲属中有痴呆家族史是否会影响阿尔茨海默病（AD）的进展。患者在法国阿尔茨海默病研究网络（REAL.FR）研究中招募，每六个月接受行为、整体、营养和医学评估，并评估认知功能和独立性。纳入研究时，113名患者报告有痴呆家族史，358名患者无痴呆家族史。两组在基线时的任何因素均无统计学差异。随访两年后，每组仍有相似比例的患者接受随访，尽管大多数参数显示有显著恶化，但两组之间无差异，这表明痴呆家族史似乎不会影响AD的进展。
