Benoit M, Staccini P, Brocker P, Benhamidat T, Bertogliati C, Lechowski L, Tortrat D, Robert P H
Centre mémoire de ressources et de recherches du CHU de Nice, hôpital Pasteur, 30, avenue de la Voie-Romaine, 06002 Nice, France.
Rev Med Interne. 2003 Oct;24 Suppl 3:319s-324s. doi: 10.1016/s0248-8663(03)80690-2.
Behavioral and Psychological Signs and Symptoms of Dementia (BPSD) are important manifestations of Alzheimer's Disease (AD) and other forms of dementia, because they are associate with care-giver distress, increase the likelihood of institutionalization, and may be associated with more rapid cognitive decline In this study (REAL.FR for Réseau sur la maladie d'Alzheimer Français) we prospectively used the Neuropsychiatric Inventory NPI to examine BPSD. 255 AD patients with a Mini-Mental State Examination (MMSE) score between 11 and 20 and 244 AD patients with a MMSE between 21 and 30 were examined. Factor analysis was carried out leading to three different syndromes according to the level of cognitive impairment. BPSD were detected in 92.5% of the patients with a MMSE between 11 and 20, and in 84% of the patients with a MMSE between 21 and 30. Apathy was the most common abnormality, followed by anxiety and dysphoria. These results in a French cohort of patients with AD underline the importance of the evaluation and finally of the treatment of BPSD.
痴呆的行为和心理症状（BPSD）是阿尔茨海默病（AD）和其他形式痴呆的重要表现，因为它们与照料者的痛苦相关，增加了入住养老院的可能性，并且可能与认知功能的更快衰退有关。在本研究（法国阿尔茨海默病研究网络的REAL.FR）中，我们前瞻性地使用神经精神科问卷（NPI）来检查BPSD。对255名简易精神状态检查表（MMSE）评分在11至20之间的AD患者和244名MMSE评分在21至30之间的AD患者进行了检查。根据认知障碍水平进行因子分析，得出三种不同的综合征。MMSE评分在11至20之间的患者中，92.5%检测到BPSD；MMSE评分在21至30之间的患者中，84%检测到BPSD。冷漠是最常见的异常，其次是焦虑和烦躁不安。这些在法国AD患者队列中的结果强调了评估以及最终治疗BPSD的重要性。
