Aliphas Avner, Prufer Neil, Grundfast Kenneth M
Boston Medical Center, Department of Otolaryngology--Head & Neck Surgery, 88 East Newton Street, D616 Boston, MA 02118, USA.
Expert Opin Emerg Drugs. 2006 May;11(2):251-64. doi: 10.1517/14728214.11.2.251.
Otitis media is one of the most common disorders occurring in children, and there is growing concern that bacteria are quickly becoming resistant to antimicrobials. As a result, global antibiotic treatment is no longer the standard of care and treatment of otitis media has changed dramatically in the last decade. In addition to new antimicrobials currently in development, the effects of the pneumococcal conjugate vaccine are just beginning to be understood. Furthermore, new surgical techniques are for the first time being tested as alternatives for tympanostomy tubes for recurrent acute otitis media. This review discusses current and emerging otitis media therapeutics, with particular attention to acute otitis media. Topics include antimicrobial use, antimicrobial resistance, effects of vaccination and new surgical techniques.
中耳炎是儿童最常见的疾病之一，人们越来越担心细菌对抗菌药物迅速产生耐药性。因此，全球范围内抗生素治疗已不再是中耳炎的标准治疗方法，在过去十年中，中耳炎的治疗发生了巨大变化。除了目前正在研发的新型抗菌药物外，肺炎球菌结合疫苗的作用才刚刚开始被了解。此外，新的外科技术首次被测试作为复发性急性中耳炎鼓膜置管的替代方法。本综述讨论了当前和新兴的中耳炎治疗方法，尤其关注急性中耳炎。主题包括抗菌药物的使用、抗菌药物耐药性、疫苗接种的影响和新的外科技术。
