Hayes P C, May L, Hayes J D, Harrison D J
Department of Medicine, University of Edinburgh.
Gut. 1991 Dec;32(12):1546-9. doi: 10.1136/gut.32.12.1546.
An immunohistochemical study of glutathione S-transferase (GST) expression in hepatocellular carcinoma and cholangiocarcinoma is described. Unlike most animal models of hepatic malignancy pi class GST was not consistently overexpressed in hepatocellular carcinoma. This tumour type either predominantly expressed alpha class GST or failed to express GST. By contrast, cholangiocarcinoma always expressed pi class GST, presumably reflecting the tissue of origin, since in human biliary epithelium pi class GST is the predominant GST. The variable expression of pi class GST which was observed in hepatocellular carcinoma may reflect transformation of hepatocytes damaged by toxins, since this GST can be induced after a chemical insult such as alcohol. As well as indicating the biochemical heterogeneity of hepatocellular carcinoma with respect to GST, this study indicates the need for further study of the nature of inherent drug resistance in these tumour types.
本文描述了一项关于谷胱甘肽S-转移酶（GST）在肝细胞癌和胆管癌中表达的免疫组织化学研究。与大多数肝恶性肿瘤动物模型不同，π类GST在肝细胞癌中并非始终过度表达。这种肿瘤类型要么主要表达α类GST，要么不表达GST。相比之下，胆管癌总是表达π类GST，这可能反映了其起源组织，因为在人胆管上皮中，π类GST是主要的GST。在肝细胞癌中观察到的π类GST的可变表达可能反映了受毒素损伤的肝细胞的转化，因为这种GST可在化学损伤（如酒精）后被诱导。这项研究不仅表明了肝细胞癌在GST方面的生化异质性，还表明有必要进一步研究这些肿瘤类型中固有耐药性的本质。
