Howlett T A, Grossman A, Froud A, Perry L, Besser G M
Department of Endocrinology, St. Bartholomew's Hospital, London, England.
Horm Metab Res. 1991 Jul;23(7):341-3. doi: 10.1055/s-2007-1003692.
Eight normal male subjects received 1 mg dexamethasone at 23.00 h and 0.5 mg on wakening followed by a physiological intravenous dose of synthetic ACTH1-24 250 ng, with and without the administration of a stable met-enkephalin analogue (guanyl-DAMME, 100 micrograms) 10 minutes prior to the ACTH. The opioid analogue caused no change in the peak, incremental, or incremental area under the curve responses of plasma cortisol to the ACTH. This study does not support a role for opioid peptides in the acute modulation of the adreno-cortical response to ACTH.
八名正常男性受试者于23:00时接受1毫克地塞米松，醒来后再接受0.5毫克，随后静脉注射生理剂量的合成促肾上腺皮质激素1-24（250纳克），分别在注射促肾上腺皮质激素前10分钟给予和不给予稳定的甲硫氨酸脑啡肽类似物（胍基-DAMME，100微克）的情况下进行。该阿片类类似物对血浆皮质醇对促肾上腺皮质激素的峰值、增量或曲线下增量面积反应没有影响。这项研究不支持阿片肽在促肾上腺皮质激素对肾上腺皮质反应的急性调节中起作用。
