Redekopp C A, Livesey J H, Donald R A
Horm Metab Res. 1985 Dec;17(12):646-9. doi: 10.1055/s-2007-1013634.
The effect of IV injections of an enkephalin analogue (DAMME) in sheep prior to the administration of CRF has been compared with chlorpromazine-morphine (CPZ-M) injections as well as a chlorpromazine-morphine-nembutal (CPZ-M-N) regime. The results showed that the administration of DAMME 60 minutes prior to CRF injections, gave more consistent and more sustained inhibition of spontaneous plasma ACTH and plasma cortisol secretion than either CPZ-M or CPZ-M-N pre-treatment. Changes in plasma ACTH and plasma cortisol levels were more readily detectable in DAMME-treated sheep as compared with saline controls when 50 micrograms injections of CRF were given into the carotid artery. This suggests that DAMME may inhibit endogenous CRF release by an action at hypothalamic level or above.
在给予促肾上腺皮质激素释放因子（CRF）之前，对绵羊静脉注射脑啡肽类似物（DAMME）的效果与注射氯丙嗪-吗啡（CPZ-M）以及采用氯丙嗪-吗啡-戊巴比妥（CPZ-M-N）方案的效果进行了比较。结果显示，在注射CRF前60分钟给予DAMME，与CPZ-M或CPZ-M-N预处理相比，能更持续、更稳定地抑制血浆促肾上腺皮质激素（ACTH）和血浆皮质醇的自发分泌。当向颈动脉注射50微克CRF时，与生理盐水对照组相比，在接受DAMME治疗的绵羊中，血浆ACTH和血浆皮质醇水平的变化更容易被检测到。这表明DAMME可能通过作用于下丘脑或更高水平来抑制内源性CRF的释放。
