Rossolini G, Viticchi C, Basso A, Zaia A, Piantanelli L
Centre of Biochemistry, Gerontol. Res. Department INRCA, Ancona, Italy.
Int J Neurosci. 1991 Jul;59(1-3):143-50. doi: 10.3109/00207459108985457.
It has previously been demonstrated that thymus exerts a regulatory influence on beta-adrenergic system during aging. In particular, it has been shown that thymus can correct the beta-adrenoceptor density decrease in old mice. In the present paper results of experiments are reported dealing with the influence of the thymus on alpha-adrenoceptors of mouse brain cortex. Both subtypes of alpha-adrenoceptors are studied separately, using different labelled ligands. Results show that alpha 1-adrenoceptor density decreases in old animals, while alpha 2-adrenoceptor density does not change significantly. A neonatal thymus grafted into old recipients is capable of correcting the alteration observed in old mice. The differential impairment of alpha-adrenoceptors resembles that one previously observed on beta-adrenoceptors, where beta 1-type decreases in number during aging with a parallel decrease of adenylyl-cyclase activity, while beta 2-type remains unchanged.
先前已经证明，胸腺在衰老过程中对β-肾上腺素能系统发挥调节作用。特别是，已经表明胸腺可以纠正老年小鼠β-肾上腺素能受体密度的降低。在本文中，报告了关于胸腺对小鼠大脑皮质α-肾上腺素能受体影响的实验结果。使用不同的标记配体分别研究了α-肾上腺素能受体的两种亚型。结果表明，老年动物中α1-肾上腺素能受体密度降低，而α2-肾上腺素能受体密度没有显著变化。移植到老年受体中的新生胸腺能够纠正老年小鼠中观察到的改变。α-肾上腺素能受体的差异性损伤类似于先前在β-肾上腺素能受体上观察到的损伤，其中β1型在衰老过程中数量减少，同时腺苷酸环化酶活性平行下降，而β2型保持不变。
