发育和衰老过程中胸腺对大脑皮质β-肾上腺素能受体的调节

Thymic regulation of brain cortex beta-adrenoceptors during development and aging.

作者信息

Piantanelli L, Gentile S, Fattoretti P, Viticchi C

出版信息

Arch Gerontol Geriatr. 1985 Jul;4(2):179-85. doi: 10.1016/0167-4943(85)90032-9.

Abstract

The influence of the thymus on beta-adrenoceptors has been studied in the brain cortex of mice during developing and aging. Affinity of beta-adrenoceptors shows no statistically significant changes in the various animal models investigated. Receptor density shows a fall in both athymic nude mice and in old normal mice. Receptor density, in particular, decreases progressively with advancing age. It has been demonstrated that thymus exerts a regulatory role in both development and aging, as a neonatal thymic graft is capable of reversing the receptor impairments found in young athymic nude mice and in old normal mice.

摘要

在小鼠发育和衰老过程中，研究了胸腺对其大脑皮质中β-肾上腺素能受体的影响。在所研究的各种动物模型中，β-肾上腺素能受体的亲和力未显示出统计学上的显著变化。受体密度在无胸腺裸鼠和老年正常小鼠中均有所下降。特别是，受体密度随着年龄的增长而逐渐降低。已经证明，胸腺在发育和衰老过程中均发挥调节作用，因为新生胸腺移植能够逆转在年轻无胸腺裸鼠和老年正常小鼠中发现的受体损伤。